How does CBD work

This is a topic that can go ridiculous deep, ill try to make it readable without sounding like a medical journal, but I’ve been asked to elaborate on my”what are CBD’s topic’ so grab a comfortable chair, as we begin…

How does CBD work

Before we can understand how CBD works, we need to understand how we work, at least for CBD sake.

The “endocannabinoid system” or ECS is a series of receptors that runs thru our body. They are used to maintain and control our daily functions, studies are still relatively in their infancy but are progressing rapidly.

So how does CBD work? CBD or cannabidiol is a non-intoxicating compound of the cannabis family which includes hemp. Although scientists and doctors have been researching it for years the exact process is still not truly understood, taking it to a molecular level is a good starting point. Cannabidiol is a phototropic drug meaning it produces many effects in many molecular paths. Scientists have identified over 60 molecular targets of CBD, of the two cannabinoid receptors CB1 works with the central nervous system. CB2 works with the immune cells, gastrointestinal tract and peripheral nervous system.  CBD has very little binding properties for either, CBD acts through various receptors through independent paths, it can delay reuptake of endogenous neurotransmitters and enhance or inhibiting the binding action of certain G-protein coupled receptors.

Serotonin Receptors

Researcher’s from London, Brazil, and Israel have been conducting groundbreaking research into CBD and the neural correlates of anxiety. At high concentrations, CBD directly activates the serotonin receptor, thereby conferring an anti-anxiety effect. This g coupled protein receptor is implicated in a wide range of biological and neurological processes including anxiety, addiction, appetite, pain, sleep, nausea, and vomiting. 5-ht receptors are activated by serotonin, its found in both the central and peripheral nervous systems.

The one we will concentrate on is 5HT1A, the 5-ht receptors trigger chemical messages to produce an expiatory or inhibitory response, depending on the chemical content of the message. Both THC and CBD start as THCA and CBDA the ”A” in the compound are acid when heated the acid is removed, but if kept in its raw form CBDA could work better than CBD and is a strong anti-emetic, both CBD and THC have strong anti-nausea properties.


CBD  works with various channels that cause therapeutic effects. They bind to TRPV1  receptors, these receptors are known to mediate pain perception, body temperatures, and inflammation. TRPV receptors work to mediate the effects of a broad range of herbs, and drugs CBD binds to trpv1 which can influence the way receptors to deal with adversity.
Ion channels have the ability to control the release of chemicals like calcium, sodium, and potassium, CBD can delay the reabsorption of neurotransmitters or brain chemicals. As a result, CBD gives chemicals more time to stay in your body.


CBD activates the 5-hta1a serotonin receptors and the ion channels, studies show that CBD acts as a blocker and actually deactivates another G protein receptor known as GPR55. Because scientists are not sure what family it belongs to it is called, an orphan receptor, its mainly used in the brain, especially in the cerebellum and works with blood pressure, bone density, and other physiological processes.

`GPR55 is associated with bone reabsorption which helps with osteoporosis. When activated it also promotes cancer cell proliferation. CBD also has an anti-cancer effect by activating PPAPRs which are located on the cell’s nucleus. By activating these receptors the ability to regress tumors in human lung cancer has been noted.  Also by degrading amyloid-beta plaque, CBD has been found to be a useful remedy of Alzheimer’s patents. A  PPAR receptor also helps in insulin sensitivity, lipid uptake, and metabolic functions. This could help in the treatment of Diabetics.


As we continue to advance our research with CBD, scientists from all over the world are breaking down, adding different combinations and discovering new uses for the compounds. Without going into each individual disease or ailment we can say it works with our receptors. It can reshape the receptor to block, filter and change the way the receptor transmits singles in our body. We have found it can be extracted and isolated or mixed in an unlimited level of strengths, it works in the brain, nerves, blood
and digestive tracts and its been shown to reduce addiction.

Please leave questions or comments below, thanks again.

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